Monday, 14 May 2018

Osler-Weber-Rendu Disease (Hereditary Hemorrhagic Telangiectasia)

Osler-Weber-Rendu Disease (Hereditary Hemorrhagic Telangiectasia)Osler-Weber-Rendu disease (OWRD) is a rare autosomal dominant disorder that affects blood vessels throughout the body (causing vascular dysplasia) and results in a tendency for bleeding. The prognosis varies, depending on the severity of symptoms; generally, it is good, as long as bleeding is promptly recognized and adequately controlled.
 HHT is manifested by mucocutaneous telangiectases and arteriovenous malformations (AVMs), a potential source of serious morbidity and mortality.  Lesions can affect the nasopharynx, central nervous system (CNS), lung, liver, and spleen, as well as the urinary tract, gastrointestinal (GI) tract, conjunctiva, trunk, arms, and fingers
 What Causes Osler-Weber-Rendu Syndrome? People with OWR inherit an abnormal gene that causes their blood vessels to form incorrectly. OWR is an autosomal dominant disorder. This means that only one parent needs to have the abnormal gene to pass it on to their children. OWR doesn’t skip a generation. However, the signs and symptoms may vary greatly between family members. If you have OWR, it’s possible that your child could have a milder or more severe course than you.
In very rare cases, a child can be born with OWR even when neither parent has the syndrome. This happens when one of the genes that cause OWR mutates in an egg or sperm cell. Diagnosing Osler-Weber-Rendu Syndrome The presence of telangiectasias is one indication of OWR. Other clues that might lead to a diagnosis include:·         frequent nosebleeds
·         anemia
·         bloody stools
·         having a parent with the syndrome
If you have OWR, you should be screened for AVMs in the lungs and brain. This can help your doctor detect a potentially dangerous problem before something goes wrong. An MRI can screen for problems in the brain. CT scans can detect lung AVMs.Your doctor can monitor the ongoing symptoms of this syndrome through regular checkups.Genetic testing isn’t usually needed to diagnose OWR. These tests are expensive and may not be available in all circumstances. People with a family history of OWR who are interested in genetic testing should discuss their options with a genetic counselor.

Friday, 11 May 2018

Acute stroke in sickle cell disease

Acute stroke in sickle cell disease

Stroke is a common and potentially devastating manifestation of sickle cell disease (SCD) that can affect children and adults. Challenges in management include distinguishing acute stroke from other cerebrovascular manifestations of the disease such as meningitis, cerebral malaria, or seizure disorder, and distinguishing acute ischemic stroke from hemorrhagic stroke. Care of the patient with an acute stroke requires specialized expertise in exchange transfusion practices.
Want to unleash your research ideas related stroke?
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Thursday, 10 May 2018

Facts about Cerebral Palsy

Cerebral Palsy (CP) is a term used often to describe those who have abnormalities of body movement, balance and posture occurring from abnormal neurological processes. The mechanism(s) that causes CP occurs more frequently during prenatal life as the fetus develops, from infections, abnormalities of the placenta, fetal stroke, genetic abnormalities, developmental abnormalities of the fetal brain, trauma to the mother, premature delivery, and other causes, or after birth from inborn metabolic disorders, epilepsy, neurotransmitter disorders, and other causes.
Here are 6 interesting facts you need to know about CP:
  • Cerebral Palsy (CP) is the most common motor disability in childhood.
  • CP affects 1 in 500 newborns.
  • CP is a congenital disorder of movement, muscle tone and or posture.
  • Globally, over 17 million people have CP.
  • Symptoms of CP vary from person to person.
  • There is no known cure for CP, but treatment can improve the lives of those who have the condition. It is important to begin a treatment program as early as possible.
To share your knowledge about Cerebral Palsy, Submit an Abstract

Wednesday, 9 May 2018

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Friday, 4 May 2018

Renowned Speakers at Pediatric Neurology 2018!

Renowned Speakers at Pediatric Neurology 2018

·         Muhammad Akbar MALIK, Top-Down-Bottom-Up, Pakistan
·         Ying Peng, Sun Yat-Sen University, China
·         Fadia El Bitar, King Faisal Specialist Hospital and Research Centre, Saudi Arabia
·         Soheil Kazemi Roodsari, Tehran University of Medical Sciences, Iran
·         Xiaoni Zhang, Sun Yat-Sen University, China
·         Farzad Ahmadabadi, Child Neurologist Ardabil medical sciences university,  Iran
·         Elham Ataei, Assistant University of Medical Sciences, Iran
·         Bingsheng Huang, Professor Shenzhen University, China
·         Ailian Du, Shanghai Jiaotong University School of Medicine,  China
For more details, Please visit
To present your research work, please do submit an abstract at

Sunday, 22 April 2018

Electrographic Seizures in Pediatric Systemic Cancer Patients with acute Unexplained Encephalopathy Diagnostic role of Bedside Emergent 30min EEG

Keynote Presentation at Pediatric Neurology 2018!

Muhammad Akbar Malik was trained in General Pediatrics in Pakistan and then was trained in Pediatric Neurology in Frenchay Hospital Bristol, UK. He established Pediatric Neurology department and worked for five years in Lahore Children Hospital. Now he heading a charity project: Top-Down-Bottom-Up project, aiming to provide pediatric neurology services at door-steps of out-reached poor communities in Pakistan.
Statement of the Problem: Systemic pediatric cancer patients are prone to become critically ill and may develop seizures and encephalopathy, which can result in permanent neurologic disability. There are few techniques for monitoring brain functions in these patients, especially in resource-poor settings. The emergent bed-side electroencephalogram (EEG) can be useful. Purpose: to determine, usefulness of emergent bedside EEG features among these patients with unexplained coma (GCS≤8) of ≤6 hrs duration. Methodology & Theoretical Orientation: Prospective EEG assessment of 40 systemic cancer patients consecutively diagnosed and admitted in neurointensive care units. Patients with brain tumor, brain metastasis, seizures or those with known cause of coma were excluded. Findings: Over a period of 2 year, 40 children; boys 65% and girls 35%, with systemic cancer patients with a median age of 9.8 years were studied. This cohort underwent bed-side EEG of ≥ 30 minutes, which was abnormal in 100% of the records. The most common EEG abnormalities were invariant mixed theta-delta slowing (27.5%), followed by low-amplitude delta pattern plus epileptiform discharges (20%) and there was electrographic evidence of EEG seizures in 17(42.5%) of the cohort. These electrographic seizures were present in 55.5% of 18 patients with subtle convulsions, whereas were documented only in 20% of the 22 patients without such movements. Electrographic seizures among patients with subtle convulsions responded to anticonvulsant drugs in 75% cases as compared 50% such response among patients without such convulsions. Conclusion& Significance: seizures are common among critically ill children with systemic cancer. Bed-side EEG record of ≥30 minutes is useful in such patients. Recommendations are made for emergent ≥ 30min EEG among systemic cancer patients with unexplained acute coma.

Wednesday, 11 April 2018

Pediatric Neurology 2018!

Pediatric neurology deals with the analysis and management of neurological conditions in newborns, infants, children and adolescents. The discipline of child neurology involves Cerebrovascular Disease, Demyelinating Disease, Developmental and Behavioral Problems, Genetic Disorders that affect people in these age groups. The advancements paved way for the pediatric neurologists to deal with conditions that vary considerably, from relatively simple disorders to more complex and infrequent conditions such as metabolic disease or Neurodegenerative Disorders.
If a child has problems that involve the nervous system, a pediatric neurologist has the specialist training and knowledge to judge, diagnose and treat the child. The conditions dealt with by pediatric neurologists vary considerably, from relatively simple disorders such as migraine or cerebral palsy through to more complex and rare conditions such as metabolic disease or neurodegenerative disorders.
Examples of the types of conditions encountered by specialists in this field include:
  • Genetic diseases of the nervous system
  • Congenital metabolic abnormalities that affect the nervous system
  • Congenital birth defects affecting the brain and spinal cord such as spina bifida
  • Neurological developmental problems during childhood
  • Childhood epilepsy
  • Febrile seizures
  • Movement disorders such as cerebral palsy
  • Progressive neuromuscular conditions such as muscular dystrophy
  • Abnormal mental development, speech disabilities and learning disabilities
  • Autism spectrum disorders
  • Behavioral disorders such as attention deficit hyperactivity disorder
  • Headaches and migraine
  • Hydrocephalus or excess fluid build-up in the brain
  • Head injuries and their complications
  • Brain tumors
  • Hospice and palliative medicine
  • Neuromuscular medicine
  • Sleep disorders
  • Vascular neurology
  • Intellectual disability
Pediatric neurologists act as consultants to primary care physicians, who may refer children to the neurologists for specialist care. For children with long-term neurological ailments, the pediatric neurologist provides regular care and consultation.
Child neurologists are found in a variety of medical environments ranging from children’s hospitals through to outpatient practices, university medical centers and private clinics. They combine their understanding of diagnosis and treatment of the nervous system with expertise in childhood disorders and children’s special needs.
Overall, about 40% to 50% of the patients treated in a typical pediatric neurology practice have epilepsy, while 20% have learning difficulties or developmental problems and 20% are suffering from headaches. The remainder are treated for rare or unusual conditions such as metabolic or genetic disease. Many centers are equipped with the specialized facilities and knowledge needed to treat very specific disorders such as rare neurodegenerative conditions, intractable epilepsy or pediatric stroke.
For more interesting discussions, join the Global Experts meet on June 18-19, at Rome, Italy.
Few more speaker slots are available! Submit an abstract.

Note: Avail discounts on group registration!
          1 complementary pass for faculty on 10 student registration.

Osler-Weber-Rendu Disease (Hereditary Hemorrhagic Telangiectasia)

Osler-Weber-Rendu Disease (Hereditary Hemorrhagic Telangiectasia) Osler-Weber-Rendu disease (OWRD) is a rare autosomal dominant diso...